In Isaac Shall Thy Seed Be Called by William Bell The problem most have with interpreting the "seed" in Jeremiah 31:35-37 is beginning in the "middle" or at the "end" rather than at the beginning. God defined the "seed" of Abraham in Gen. 12:7; 21:12; 22:18 (which by the way is none other than the "seed" in Gen. 3:15). He said, "In Isaac shall thy seed be called". A significant point about Isaac is that God commands Abraham to "kill him" (offer him as a sacrifice) which he did (Gen. 22:1-12; Heb. 11:17-19). The significance of this point is missed. Isaac was Abraham's natural ...